TANGO: Transparent heterogeneous hardware Architecture deployment for eNergy Gain in Operation

The paper is concerned with the issue of how software systems actually use Heterogeneous Parallel Architectures (HPAs), with the goal of optimizing power consumption on these resources. It argues the need for novel methods and tools to support software developers aiming to optimise power consumption resulting from designing, developing, deploying and running software on HPAs, while maintaining other quality aspects of software to adequate and agreed levels. To do so, a reference architecture to support energy efficiency at application construction, deployment, and operation is discussed, as well as its implementation and evaluation plans.Comment: Part of the Program Transformation for Programmability in Heterogeneous Architectures (PROHA) workshop, Barcelona, Spain, 12th March 2016, 7 pages, LaTeX, 3 PNG figure

Towards Configurable ISO 29110-compliant Software Development Processes for Very Small Entities

International audienceUsing ISO/IEC 29110, very small entities (VSEs) can perform a step-wise increment of their software process by switching between the different ISO/ IEC profiles. However, ISO/IEC 29110 provides no guidance on how to switch between profiles incrementally, other than resorting to costly software development process experts unaffordable for VSEs. To address this shortcoming, this paper shows how to model the variability of currently available ISO/IEC 29110 profiles in an integrated and configurable workflow with illustration on the Requirements Engineering (RE) activity. This workflow is linked to a questionnaire used to support automated process configuration. Thereby, the user can easily derive the ISO/IEC-compliant processes to switch between profiles incrementally. The feasibility of this approach is shown using open-source workflow management tools Synergia and YAWL

Energy efficiency embedded service lifecycle: Towards an energy efficient cloud computing architecture

The paper argues the need to provide novel methods and tools to support software developers aiming to optimise energy efficiency and minimise the carbon footprint resulting from designing, developing, deploying and running software in Clouds, while maintaining other quality aspects of software to adequate and agreed levels. A cloud architecture to support energy efficiency at service construction, deployment, and operation is discussed, as well as its implementation and evaluation plans.Postprint (published version

16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy

Rolandic epilepsy (RE) is the most common idiopathic focal childhood epilepsy. Its molecular basis is largely unknown and a complex genetic etiology is assumed in the majority of affected individuals. The present study tested whether six large recurrent copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2, 16p13.11 and 22q11.2 previously associated with neurodevelopmental disorders also increase risk of RE. Our association analyses revealed a significant excess of the 600 kb genomic duplication at the 16p11.2 locus (chr16: 29.5-30.1 Mb) in 393 unrelated patients with typical (n = 339) and atypical (ARE; n = 54) RE compared with the prevalence in 65 046 European population controls (5/393 cases versus 32/65 046 controls; Fisher's exact test P = 2.83 × 10−6, odds ratio = 26.2, 95% confidence interval: 7.9-68.2). In contrast, the 16p11.2 duplication was not detected in 1738 European epilepsy patients with either temporal lobe epilepsy (n = 330) and genetic generalized epilepsies (n = 1408), suggesting a selective enrichment of the 16p11.2 duplication in idiopathic focal childhood epilepsies (Fisher's exact test P = 2.1 × 10−4). In a subsequent screen among children carrying the 16p11.2 600 kb rearrangement we identified three patients with RE-spectrum epilepsies in 117 duplication carriers (2.6%) but none in 202 carriers of the reciprocal deletion. Our results suggest that the 16p11.2 duplication represents a significant genetic risk factor for typical and atypical R